March 5th, 2008 by Mylo
A new study suggests that a genetic fingerprint associated with normal embryonic stem cells may be important for the development and function of cancer stem cells. The research in Cell Stem Cell demonstrates that embryonic stem cells and multiple types of human cancer cells share a genetic expression pattern that is repressed in normal differentiated cells, a finding that may have significant clinical implications for cancer therapeutics.
“Self-renewal is a hallmark of stem cells and cancer, but existence of a shared stemness program remains controversial,” explains study co-author, Dr. Howard Y. Chang from Stanford University. Dr. Chang, Dr. Eran Segal from the Weizmann Institute in Israel and their colleagues constructed a gene module map to systematically relate transcriptional programs in embryonic stem cells (ESCs), adult tissue stem cells and human cancers.
The researchers identified two predominant gene modules that distinguish ESCs and adult tissue stem cells. “Importantly, the ESC-like transcriptional program was activated in diverse human epithelial cancers and strongly predicted metastasis and death,” says Dr. Segal. Conversely, the adult tissue stem gene module had an opposite pattern, activated in normal tissues relative to cancer and repressed in various human cancers when compared to normal tissues. Read the rest of this entry »
December 24th, 2007 by Mylo
#1 Your Hand Can Have A Mind On Its Own
Remember Devon Sawa’s character in 1999’s ‘Idle Hands’, a comedy / horror movie about a teen whose hand becomes possessed and goes on a killing spree?
Apparently this movie has some truth in it. The ‘idle hand’ which referred to as the ‘Alien Hand Syndrome’ is an unusual neurological disorder in which the sufferer’s hand seems to take on a mind of its own. This is due to the damage in the medial motor frontal region of the brain and often occurs after a brain surgery, a stroke or an infection of the brain.
The sufferer has no control over the movements of the ‘alien hand’ nor will they have any conscience idea on what that hand is doing. The person suffering from this condition can often feel disconnected with their hand, and feel as if it was not part of their body.
When the suffer is unaware the alien hand can sometime act out complex movements like unbuttoning clothing, using tools or even tearing pieces of clothing. There are no know treatments or cure for ‘Alien Hand Syndrome’ however the best solution is to give this alien hand an object it can play with to keep it distracted from doing anything harmful to the sufferer.
#2 You Could Remove A Large Part of Your Internal Organs and Survive
While the human body may appear fragile, your body is stronger than you could possibly imagine. It is possible for you to survive even after the removal of the spleen, the stomach, one kidney, one lung, 75% of the liver, 80% of the intestines, and almost every organ from the pelvic and groin area. Read the rest of this entry »